Lymph vessel morphogenesis

Across TCGA patient cohorts, RNA activity of the Lymph vessel morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PTPN14_S314, PEAK1_S826, and PTPN14_S642, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lymph vessel morphogenesis activity versus PTPN14_S314 in OV (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PTPN14_S314 →	+0.501	+0.616	<.001	<.001	3	5
UCEC	PEAK1_S826 →	+0.503	+0.615	<.001	.001	3	4
BRCA	PTPN14_S642 →	+0.498	+0.467	<.001	<.001	3	4
UCEC	ZYX →	+0.447	+0.457	<.001	.001	2	4
OV	STARD13_S589 →	+0.781	+0.818	<.001	<.001	3	3
OV	MYLK_S1779 →	+1.385	+0.586	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036303 vs PTPN14_S314 — OV

Explore this scatter interactively →