Lymph vessel morphogenesis

Across TCGA cell cohorts, RNA activity of the Lymph vessel morphogenesis pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPN14, GABBR1, and ITGAV, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTPN14 grouped by Lymph vessel morphogenesis-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PTPN14 →	-0.194	-0.828	.001	.004	2	6
CNS	GABBR1 →	-0.217	-1.008	.001	<.001	3	4
URINARY_TRACT	ITGAV →	+0.943	+1.670	.007	<.001	1	6
LUNG_NSCLC_LUAD	RAET1G →	-0.163	-0.681	.001	.002	3	4
BREAST	PDPN →	-0.167	-0.424	.005	.006	1	6
LARGE_INTESTINE	ZNF136 →	+0.247	+0.291	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTPN14 by Lymph vessel morphogenesis activity — CNS

Explore this box plot interactively →