Lymph vessel morphogenesis

Across TCGA cell cohorts, RNA activity of the Lymph vessel morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRIM1, ZSWIM5, and CNFN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CRIM1 grouped by Lymph vessel morphogenesis-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CRIM1 →	-3.338	-0.335	<.001	<.001	3	4
LUNG_SCLC	ZSWIM5 →	+1.877	+0.261	.003	.002	3	4
OVARY	CNFN →	+1.275	+0.902	.008	.009	3	4
CNS	JTB →	+0.647	+1.105	<.001	<.001	3	4
CNS	SAMD4B →	+0.589	+0.815	.008	.002	3	4
LIVER	INSYN2B →	-1.730	-1.056	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CRIM1 by Lymph vessel morphogenesis activity — LUNG_SCLC

Explore this box plot interactively →