Atrioventricular canal development

Across TCGA patient cohorts, RNA activity of the Atrioventricular canal development pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBX2, ADAMTS9-AS2, and GAPDHP15, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Atrioventricular canal development activity versus TBX2 in CCRCC (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TBX2 →	+1.065	+1.026	<.001	<.001	3	5
LSCC	ADAMTS9-AS2 →	+0.542	+0.429	<.001	<.001	2	6
CCRCC	GAPDHP15 →	+0.381	+0.859	<.001	<.001	3	5
CCRCC	NEURL1 →	+0.187	+0.823	.001	.001	3	4
HNSC	TBC1D30 →	+0.465	+0.435	<.001	.003	3	4
CCRCC	FHL5 →	+0.933	+0.658	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036302 vs TBX2 — CCRCC

Explore this scatter interactively →