Atrioventricular canal development

Across TCGA cell cohorts, RNA activity of the Atrioventricular canal development pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MORN1, RHBDD3, and ENDOV, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MORN1 grouped by Atrioventricular canal development-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MORN1 →	+0.790	+1.204	.001	.001	3	4
CNS	RHBDD3 →	+0.552	+0.933	.007	.004	3	3
CNS	ENDOV →	+0.913	+1.019	<.001	<.001	3	3
CNS	ARHGEF28 →	-0.892	-0.610	.004	.003	3	3
BLOOD_Leukemia	IDH1 →	+1.284	+1.047	.006	.006	3	3
SKIN	PIEZO2 →	-1.844	-1.104	.004	.002	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MORN1 by Atrioventricular canal development activity — SKIN

Explore this box plot interactively →