Atrioventricular canal development

Across TCGA cell cohorts, RNA activity of the Atrioventricular canal development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF136, SPTY2D1OS, and COPS3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Atrioventricular canal development activity versus ZNF136 in BLOOD_Leukemia (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZNF136 →	+0.592	+0.523	.002	.007	3	5
OESOPHAGUS	SPTY2D1OS →	-0.920	-0.253	.005	.008	2	5
BLOOD_Leukemia	COPS3 →	+0.696	+0.871	<.001	<.001	3	4
BLOOD_Leukemia	CTC1 →	+0.991	+0.868	.001	<.001	3	4
STOMACH	DSE →	-2.428	-1.239	.003	<.001	3	4
LARGE_INTESTINE	BLCAP →	-0.877	-1.121	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036302 vs ZNF136 — BLOOD_Leukemia

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