Macrophage colony-stimulating factor production

pathway activity — cross-omics
GO:0036301Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Macrophage colony-stimulating factor production pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PTGES3_S148, MTHFD1L_S357, and HAVCR2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCAPTGES3_S148 →-0.767-0.451<.001.00133
GBMMTHFD1L_S357 →-0.862-0.260<.001<.00133
OVHAVCR2 →+0.799+0.849.002.00115
BRCASHANK3_S388 →+0.925+0.872<.001<.00132
HNSCSQSTM1_S24 →+0.745+0.300<.001<.00132
BRCATPR_T1839 →-0.828-0.713.002<.00123
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration