Response to increased oxygen levels

Across TCGA patient cohorts, RNA activity of the Response to increased oxygen levels pathway is significantly associated with the RNA expression of multiple genes, with the SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCR4, PTPRC, and FYB1, each associated with the pathway in up to 31 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to increased oxygen levels activity versus CCR4 in SCLC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	CCR4 →	+1.193	+0.125	<.001	<.001	2	31
SCLC	PTPRC →	+1.994	+0.121	<.001	<.001	3	30
SCLC	FYB1 →	+2.431	+0.112	<.001	<.001	3	30
LAML	IL10RA →	+1.608	+0.051	<.001	<.001	2	30
SCLC	PTPN22 →	+1.701	+0.123	<.001	<.001	3	29
CHOL	SAMSN1 →	+1.647	+0.042	.001	.008	1	31

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036296 vs CCR4 — SCLC

Explore this scatter interactively →