Response to increased oxygen levels

Across TCGA cell cohorts, RNA activity of the Response to increased oxygen levels pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP18, GON4L, and PMF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ARHGAP18 grouped by Response to increased oxygen levels-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ARHGAP18 →	+2.096	+0.320	.006	.008	3	4
LUNG_NSCLC_LUAD	GON4L →	-0.410	-0.315	.002	.001	3	4
LARGE_INTESTINE	PMF1 →	-0.479	-0.493	<.001	.004	3	4
LUNG_NSCLC_LUSC	TSPO →	+1.017	+0.351	.005	.007	3	3
LUNG_NSCLC_LUSC	ATP1A3 →	+2.244	+0.328	<.001	<.001	3	3
LUNG_NSCLC_LUSC	PBX4 →	+1.333	+0.264	.009	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ARHGAP18 by Response to increased oxygen levels activity — STOMACH

Explore this box plot interactively →