Response to increased oxygen levels

Across TCGA cell cohorts, RNA activity of the Response to increased oxygen levels pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL30, PTPRK, and SMPD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to increased oxygen levels activity versus RPL30 in LUNG_SCLC (Pearson r = -0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RPL30 →	-0.567	-0.166	<.001	.002	3	5
STOMACH	PTPRK →	+1.871	+0.273	.003	.002	3	4
STOMACH	SMPD1 →	+2.345	+0.290	.001	.002	3	4
PANCREAS	ATP6V0C →	+0.935	+0.254	.004	.004	2	5
OVARY	ABCF2 →	-0.900	-0.281	<.001	.001	3	4
LUNG_NSCLC_LUAD	HAGH →	+0.645	+0.238	.004	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036296 vs RPL30 — LUNG_SCLC

Explore this scatter interactively →