Cellular response to increased oxygen levels

Across TCGA cell cohorts, RNA activity of the Cellular response to increased oxygen levels pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP6V1A, ATP6AP1, and ATP6V1B2, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATP6V1A grouped by Cellular response to increased oxygen levels-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ATP6V1A →	-0.397	-0.273	<.001	<.001	3	14
LIVER	ATP6AP1 →	-0.475	-0.398	.005	.004	3	10
LIVER	ATP6V1B2 →	-0.755	-0.321	.004	.001	3	8
LUNG_NSCLC_LUAD	WDR7 →	-0.350	-0.328	.002	.002	3	5
UPPER_AERODIGESTIVE_TRACT	KLF8 →	+0.134	+0.207	<.001	.005	3	5
PANCREAS	TFRC →	-0.598	-0.248	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATP6V1A by Cellular response to increased oxygen levels activity — BREAST

Explore this box plot interactively →