Cellular response to increased oxygen levels

Across TCGA cell cohorts, RNA activity of the Cellular response to increased oxygen levels pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATF7IP2, YY1AP1, and ATP6V1A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATF7IP2 grouped by Cellular response to increased oxygen levels-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ATF7IP2 →	-1.660	-0.232	.003	.002	3	4
BLOOD_Leukemia	YY1AP1 →	-0.541	-0.333	.001	.001	3	4
BREAST	ATP6V1A →	-0.729	-0.310	.002	<.001	3	3
BLOOD_Leukemia	TICAM1 →	-0.654	-0.419	.001	.009	3	3
SKIN	AMIGO3 →	-0.640	-0.254	.002	<.001	3	3
SKIN	SPACA6 →	-1.145	-0.276	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATF7IP2 by Cellular response to increased oxygen levels activity — BREAST

Explore this box plot interactively →