Cellular response to increased oxygen levels

Across TCGA cell cohorts, RNA activity of the Cellular response to increased oxygen levels pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GDI1, RPS17, and ATP6AP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to increased oxygen levels activity versus GDI1 in LIVER (Pearson r = 0.84).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	GDI1 →	+1.586	+0.363	<.001	<.001	3	6
SKIN	RPS17 →	-0.841	-0.273	<.001	<.001	3	6
SKIN	ATP6AP1 →	+1.053	+0.274	<.001	.001	3	6
LIVER	EEF1B2 →	-1.121	-0.383	<.001	<.001	3	6
LIVER	CCDC96 →	+0.944	+0.404	<.001	.003	3	6
LIVER	RPL4 →	-0.755	-0.332	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036295 vs GDI1 — LIVER

Explore this scatter interactively →