Peptidyl-serine autophosphorylation

Across TCGA patient cohorts, RNA activity of the Peptidyl-serine autophosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LY6H, VSNL1, and SOX18, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-serine autophosphorylation activity versus LY6H in COAD (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LY6H →	-0.282	-0.591	.004	.001	3	3
GBM	VSNL1 →	-1.662	-0.676	<.001	.001	3	3
GBM	SOX18 →	-0.490	-0.536	.005	.002	3	3
UCEC	TACR1 →	-0.483	-0.510	.002	.003	3	3
CCRCC	IGHJ2P →	-0.638	-0.248	.007	.003	3	3
PDAC	TAS2R3 →	+0.346	+0.586	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036289 vs LY6H — COAD

Explore this scatter interactively →