Peptidyl-serine autophosphorylation

Across TCGA cell cohorts, RNA activity of the Peptidyl-serine autophosphorylation pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERN1, TP53BP1, and ATM, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ERN1 grouped by Peptidyl-serine autophosphorylation-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	ERN1 →	-0.404	-1.650	<.001	.009	3	9
SOFT_TISSUE	TP53BP1 →	-0.376	-1.306	.001	.006	3	8
SKIN	ATM →	-0.262	-0.922	<.001	<.001	3	7
PANCREAS	MARK3 →	-0.222	-1.076	.007	.003	3	7
UPPER_AERODIGESTIVE_TRACT	RIPK1 →	-0.251	-1.306	.008	.002	2	7
SOFT_TISSUE	DYRK1A →	-0.458	-1.837	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ERN1 by Peptidyl-serine autophosphorylation activity — BONE

Explore this box plot interactively →