Peptidyl-serine autophosphorylation

Across TCGA cell cohorts, RNA activity of the Peptidyl-serine autophosphorylation pathway is significantly associated with the shRNA dependency of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACSS1, CASD1, and USP49, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACSS1 grouped by Peptidyl-serine autophosphorylation-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ACSS1 →	-0.336	-0.125	<.001	.008	3	5
STOMACH	CASD1 →	+0.160	+0.101	<.001	<.001	3	4
KIDNEY	USP49 →	+0.307	+0.149	<.001	<.001	3	4
SKIN	UHMK1 →	+0.159	+0.070	.001	.004	3	4
SKIN	TTC24 →	+0.245	+0.130	.002	<.001	3	4
OVARY	AK7 →	+0.140	+0.089	.006	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACSS1 by Peptidyl-serine autophosphorylation activity — STOMACH

Explore this box plot interactively →