RNA (guanine-N7)-methylation

Across TCGA patient cohorts, RNA activity of the RNA (guanine-N7)-methylation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BMS1, MAK16, and POLR1A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA (guanine-N7)-methylation activity versus BMS1 in LSCC (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	BMS1 →	+0.263	+0.051	<.001	.001	3	6
OV	MAK16 →	+0.449	+0.062	<.001	<.001	3	6
LSCC	POLR1A →	+0.357	+0.060	<.001	<.001	3	6
GBM	METTL1 →	+0.360	+0.049	<.001	<.001	3	5
LSCC	TBL3 →	+0.266	+0.051	<.001	<.001	3	5
OV	TRMT6 →	+0.356	+0.059	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036265 vs BMS1 — LSCC

Explore this scatter interactively →