7-methylguanosine cap hypermethylation

Across TCGA patient cohorts, RNA activity of the 7-methylguanosine cap hypermethylation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDNF, NGDN, and RNA5SP197, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, 7-methylguanosine cap hypermethylation activity versus CDNF in CCRCC (Pearson r = -0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CDNF →	-0.303	-0.055	.008	.005	3	4
COAD	NGDN →	-0.334	-0.177	.009	.005	3	3
COAD	RNA5SP197 →	-0.253	-0.153	.008	.007	3	3
LSCC	TVP23BP2 →	-0.228	-0.094	.006	<.001	3	3
COAD	DAP3P1 →	-0.401	-0.178	.001	.002	3	3
LSCC	RPS26P35 →	+0.289	+0.081	.009	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036261 vs CDNF — CCRCC

Explore this scatter interactively →