7-methylguanosine cap hypermethylation

Across TCGA cell cohorts, RNA activity of the 7-methylguanosine cap hypermethylation pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H2AC19, TMEM33, and H2BC21, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, 7-methylguanosine cap hypermethylation activity versus H2AC19 in BONE (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	H2AC19 →	+2.910	+0.192	.007	.003	3	4
OVARY	TMEM33 →	+0.833	+0.150	.009	.004	3	4
BONE	H2BC21 →	+2.957	+0.211	.004	.002	3	3
OESOPHAGUS	AARSD1 →	-0.594	-0.103	.001	.003	3	3
OESOPHAGUS	IFNGR1 →	-0.838	-0.079	.007	.005	3	3
BLOOD_Leukemia	RADX →	-1.262	-0.096	.003	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036261 vs H2AC19 — BONE

Explore this scatter interactively →