RNA capping

Across TCGA patient cohorts, RNA activity of the RNA capping pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WDHD1_S868, DNAJC2, and MCM6, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA capping activity versus WDHD1_S868 in LUAD (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	WDHD1_S868 →	+1.135	+0.042	<.001	<.001	3	7
LUAD	DNAJC2 →	+0.350	+0.048	<.001	<.001	3	7
LSCC	MCM6 →	+0.694	+0.059	<.001	<.001	3	7
LUAD	LIG1_S141 →	+0.745	+0.045	<.001	<.001	3	6
LSCC	MSN →	-0.280	-0.037	<.001	<.001	3	6
LSCC	RFC1_S368 →	+0.694	+0.055	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036260 vs WDHD1_S868 — LUAD

Explore this scatter interactively →