RNA capping

Across TCGA cell cohorts, RNA activity of the RNA capping pathway is significantly associated with the protein abundance of multiple proteins, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SNRPD1, TTC22, and YWHAB, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA capping activity versus SNRPD1 in BLOOD_Myeloma (Pearson r = 0.81).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SNRPD1 →	+0.691	+0.129	.003	.006	3	12
LUNG_SCLC	TTC22 →	+1.275	+0.113	.002	<.001	3	11
URINARY_TRACT	YWHAB →	-2.625	-0.152	<.001	<.001	3	10
SOFT_TISSUE	SRSF10 →	+0.875	+0.215	<.001	.001	3	10
OESOPHAGUS	EML6 →	-1.051	-0.126	.003	.001	2	11
URINARY_TRACT	HSP90AB1 →	-1.927	-0.152	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036260 vs SNRPD1 — BLOOD_Myeloma

Explore this scatter interactively →