Multivesicular body organization

Across TCGA patient cohorts, RNA activity of the Multivesicular body organization pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SYNE1, EIF3G, and RPS2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Multivesicular body organization activity versus SYNE1 in OV (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SYNE1 →	+0.377	+0.028	.007	.009	3	6
OV	EIF3G →	-0.296	-0.043	.002	.001	3	6
LUAD	RPS2 →	-0.165	-0.032	<.001	.001	3	5
PDAC	RPS26 →	-0.399	-0.027	.002	.002	3	5
BRCA	SEH1L →	-0.145	-0.036	<.001	<.001	3	5
LSCC	RPL6 →	-0.241	-0.034	.008	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036257 vs SYNE1 — OV

Explore this scatter interactively →