Multivesicular body organization

Across TCGA cell cohorts, RNA activity of the Multivesicular body organization pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HACD3, GARS1, and DCN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HACD3 grouped by Multivesicular body organization-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	HACD3 →	+0.238	+0.192	.004	.002	3	4
BLOOD_Myeloma	GARS1 →	+0.459	+0.226	.006	.007	3	3
BLOOD_Myeloma	DCN →	-0.270	-0.227	.001	.002	3	3
BLOOD_Myeloma	AKAP9 →	-0.333	-0.259	.002	.003	3	3
STOMACH	DDHD1 →	-0.148	-1.502	.005	.009	3	3
SKIN	AP2S1 →	+0.342	+0.196	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HACD3 by Multivesicular body organization activity — SKIN

Explore this box plot interactively →