Outer dynein arm assembly

Across TCGA patient cohorts, RNA activity of the Outer dynein arm assembly pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DPCD, DNALI1, and RASAL3_S988, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Outer dynein arm assembly activity versus DPCD in UCEC (Pearson r = 0.62).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DPCD →	+0.571	+0.158	<.001	<.001	3	7
BRCA	DNALI1 →	+0.825	+0.072	.001	.004	3	6
BRCA	RASAL3_S988 →	-0.510	-0.061	.001	<.001	3	6
UCEC	RFX2 →	+0.472	+0.154	<.001	<.001	3	5
GBM	RUVBL1 →	+0.263	+0.075	.003	.007	3	5
UCEC	SPA17 →	+1.005	+0.202	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036158 vs DPCD — UCEC

Explore this scatter interactively →