Outer dynein arm assembly

Across TCGA patient cohorts, RNA activity of the Outer dynein arm assembly pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALMS1P1, CFAP43, and LINC02546, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Outer dynein arm assembly activity versus ALMS1P1 in LSCC (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ALMS1P1 →	+0.418	+0.556	.001	<.001	3	4
LSCC	CFAP43 →	+0.703	+0.500	.003	.002	3	3
LSCC	LINC02546 →	+0.027	+0.438	.004	.001	3	3
PDAC	ISM1 →	-0.717	-0.662	.002	.003	3	3
PDAC	IGHD5-5 →	-0.683	-0.569	.003	.004	3	3
PDAC	PDZD4 →	-0.381	-0.640	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036158 vs ALMS1P1 — LSCC

Explore this scatter interactively →