Outer dynein arm assembly

Across TCGA cell cohorts, RNA activity of the Outer dynein arm assembly pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEC11C, ZNF428, and ZNF674, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SEC11C grouped by Outer dynein arm assembly-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	SEC11C →	+1.083	+1.199	.001	.002	3	4
SKIN	ZNF428 →	+0.707	+1.056	.002	.002	2	5
BLOOD_Leukemia	ZNF674 →	+0.538	+1.146	.001	.003	3	4
LUNG_SCLC	ETF1 →	-0.822	-0.933	<.001	.004	3	4
BONE	PLEKHM3 →	-0.587	-1.638	.006	.002	3	4
LIVER	HSPA6 →	-0.231	-1.215	.008	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SEC11C by Outer dynein arm assembly activity — KIDNEY

Explore this box plot interactively →