Outer dynein arm assembly

Across TCGA cell cohorts, RNA activity of the Outer dynein arm assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DNAH8, NRBP1, and DNAAF5, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Outer dynein arm assembly activity versus DNAH8 in LUNG_NSCLC_LUAD (Pearson r = 0.75).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DNAH8 →	+1.094	+1.097	<.001	<.001	3	9
BONE	NRBP1 →	+1.210	+1.276	.005	.001	3	5
LUNG_SCLC	DNAAF5 →	+1.517	+1.477	<.001	.001	3	5
SKIN	DNAH5 →	+1.646	+1.265	.001	<.001	3	5
BONE	CHMP4B →	+0.795	+1.058	.003	.005	3	4
BONE	SH3BGRL →	+1.872	+1.281	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036158 vs DNAH8 — LUNG_NSCLC_LUAD

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