Phosphatidylethanolamine acyl-chain remodeling

Across TCGA cell cohorts, RNA activity of the Phosphatidylethanolamine acyl-chain remodeling pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NGDN, ANAPC10, and MANBAL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NGDN grouped by Phosphatidylethanolamine acyl-chain remodeling-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NGDN →	-0.557	-1.358	<.001	<.001	3	3
URINARY_TRACT	ANAPC10 →	+0.534	+1.680	.007	<.001	3	3
LUNG_SCLC	MANBAL →	+0.793	+1.276	.002	.001	3	3
LUNG_SCLC	MCRIP2 →	-1.198	-1.505	.001	<.001	3	3
LUNG_NSCLC_LUAD	MED20 →	-0.407	-0.856	.008	.005	3	3
LUNG_NSCLC_LUSC	PNKD →	-1.069	-1.569	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NGDN by Phosphatidylethanolamine acyl-chain remodeling activity — LARGE_INTESTINE

Explore this box plot interactively →