Phosphatidylcholine acyl-chain remodeling

Across TCGA patient cohorts, RNA activity of the Phosphatidylcholine acyl-chain remodeling pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLA2G4A, PLA2G4A_S437, and PLA2G4A_S434, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylcholine acyl-chain remodeling activity versus PLA2G4A in COAD (Pearson r = 0.60).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PLA2G4A →	+0.513	+0.048	<.001	<.001	3	7
COAD	PLA2G4A_S437 →	+0.845	+0.043	<.001	<.001	3	7
COAD	PLA2G4A_S434 →	+0.749	+0.047	.001	.005	3	5
GBM	INPP5D_T963 →	+0.419	+0.046	<.001	<.001	3	5
GBM	RCSD1_S298 →	+0.602	+0.047	<.001	<.001	3	4
GBM	SH3BP1 →	+0.324	+0.040	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036151 vs PLA2G4A — COAD

Explore this scatter interactively →