Phosphatidylcholine acyl-chain remodeling

Across TCGA patient cohorts, RNA activity of the Phosphatidylcholine acyl-chain remodeling pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLA2G4A, IL18, and CRYZL2P, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylcholine acyl-chain remodeling activity versus PLA2G4A in UCEC (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PLA2G4A →	+1.860	+0.287	<.001	<.001	3	7
GBM	IL18 →	+0.871	+0.203	<.001	<.001	3	4
UCEC	CRYZL2P →	+0.977	+0.200	<.001	.005	3	4
UCEC	SNX24 →	+0.379	+0.282	.003	<.001	3	4
PDAC	SRSF12 →	-0.268	-0.195	<.001	.002	2	5
LUAD	MVP →	+0.336	+0.109	.005	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036151 vs PLA2G4A — UCEC

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