Phosphatidylcholine acyl-chain remodeling

Across TCGA cell cohorts, RNA activity of the Phosphatidylcholine acyl-chain remodeling pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SENP5, CBR4, and NAXE, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SENP5 grouped by Phosphatidylcholine acyl-chain remodeling-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SENP5 →	+0.655	+1.426	.004	.004	3	4
URINARY_TRACT	CBR4 →	+0.901	+1.897	<.001	<.001	3	4
SKIN	NAXE →	-0.618	-1.083	.007	.005	3	4
LARGE_INTESTINE	IRAK1BP1 →	+0.715	+0.991	.001	.005	3	4
BLOOD_Leukemia	ACTBL2 →	-0.006	-1.160	.001	.001	3	3
BLOOD_Leukemia	VPS16 →	+0.351	+0.870	.009	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SENP5 by Phosphatidylcholine acyl-chain remodeling activity — LIVER

Explore this box plot interactively →