Phosphatidylcholine acyl-chain remodeling

Across TCGA cell cohorts, RNA activity of the Phosphatidylcholine acyl-chain remodeling pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MBOAT2, LPCAT3, and NR1H3, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylcholine acyl-chain remodeling activity versus MBOAT2 in BREAST (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MBOAT2 →	+1.116	+0.106	.003	.002	3	9
STOMACH	LPCAT3 →	+1.226	+0.150	.003	.003	2	8
STOMACH	NR1H3 →	+1.816	+0.152	<.001	<.001	3	7
SKIN	KRT8 →	+1.981	+0.093	<.001	<.001	3	6
SKIN	DHRS3 →	+1.963	+0.081	.002	.002	3	6
SKIN	CDK5R1 →	-1.024	-0.071	.005	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036151 vs MBOAT2 — BREAST

Explore this scatter interactively →