Phosphatidylinositol acyl-chain remodeling

Across TCGA cell cohorts, RNA activity of the Phosphatidylinositol acyl-chain remodeling pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LCLAT1, SELENOI, and LPGAT1, each associated with the pathway in up to 20 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylinositol acyl-chain remodeling activity versus LCLAT1 in STOMACH (Pearson r = 0.82).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	LCLAT1 →	+1.115	+0.205	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	SELENOI →	+1.125	+0.167	<.001	.002	3	14
BLOOD_Myeloma	LPGAT1 →	+1.367	+0.117	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	AGPAT5 →	+1.281	+0.148	<.001	<.001	3	13
OESOPHAGUS	UBXN2A →	+0.839	+0.222	.006	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	WDR43 →	+1.077	+0.188	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036149 vs LCLAT1 — STOMACH

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