Phosphatidylglycerol acyl-chain remodeling

Across TCGA patient cohorts, RNA activity of the Phosphatidylglycerol acyl-chain remodeling pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP13A4-AS1, PRELID1P4, and C1GALT1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylglycerol acyl-chain remodeling activity versus ATP13A4-AS1 in LUAD (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ATP13A4-AS1 →	+1.112	+0.166	.003	<.001	3	4
GBM	PRELID1P4 →	+0.594	+0.156	<.001	<.001	3	4
UCEC	C1GALT1 →	+0.359	+0.182	.003	<.001	3	3
UCEC	CFAP221 →	+0.682	+0.109	.002	.009	3	3
UCEC	NOXRED1 →	+0.346	+0.117	.006	.005	3	3
UCEC	ARHGAP27P1-BPTFP1-KPNA2P3 →	+0.350	+0.136	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036148 vs ATP13A4-AS1 — LUAD

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