Phosphatidylglycerol acyl-chain remodeling

Across TCGA cell cohorts, RNA activity of the Phosphatidylglycerol acyl-chain remodeling pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAH11, ADAM19, and SMIM10L2B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DNAH11 grouped by Phosphatidylglycerol acyl-chain remodeling-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	DNAH11 →	+0.774	+1.390	.004	.001	3	4
LARGE_INTESTINE	ADAM19 →	+2.507	+0.820	<.001	.006	3	4
UPPER_AERODIGESTIVE_TRACT	SMIM10L2B →	+0.297	+1.473	<.001	.006	3	4
BLOOD_Lymphoma	TMEM243 →	+1.630	+2.093	.008	<.001	3	4
LARGE_INTESTINE	SMIM10 →	+1.475	+0.840	.006	.004	3	3
STOMACH	MAGEH1 →	+2.132	+0.937	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DNAH11 by Phosphatidylglycerol acyl-chain remodeling activity — STOMACH

Explore this box plot interactively →