Phosphatidylglycerol acyl-chain remodeling

Across TCGA cell cohorts, RNA activity of the Phosphatidylglycerol acyl-chain remodeling pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LPCAT1, PKP2, and FAM71E1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phosphatidylglycerol acyl-chain remodeling activity versus LPCAT1 in LUNG_NSCLC_LUAD (Pearson r = 0.87).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	LPCAT1 →	+2.218	+1.190	<.001	<.001	3	6
LUNG_SCLC	PKP2 →	+3.278	+1.506	<.001	.002	3	5
URINARY_TRACT	FAM71E1 →	+0.942	+1.467	.005	<.001	3	4
BREAST	CCT5 →	+1.347	+1.572	<.001	.003	3	4
BLOOD_Lymphoma	CFI →	+7.235	+1.793	<.001	.007	3	4
PANCREAS	SHROOM2 →	+2.164	+1.716	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036148 vs LPCAT1 — LUNG_NSCLC_LUAD

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