Schwann cell migration

pathway activity — cross-omics
GO:0036135Cross-omicsRNA → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Schwann cell migration pathway is significantly associated with the RNA expression of multiple genes, with the MESO cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MIR221, TIAM1, and NF1, each associated with the pathway in up to 24 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
MESOMIR221 →-1.040-0.056<.001<.001324
UCSTIAM1 →+1.576+0.098<.001<.001322
THYMNF1 →+1.182+0.074<.001<.001322
THYMMED13 →+0.989+0.069<.001<.001222
THYMSBF2 →+1.375+0.071<.001<.001222
TGCTSRBD1 →+0.710+0.043<.001<.001321
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

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