Schwann cell migration

pathway activity — cross-omics
GO:0036135Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Schwann cell migration pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DNAJC13, SRRM2_S2132, and DPYD, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMDNAJC13 →+0.181+0.102<.001<.00136
BRCASRRM2_S2132 →-0.257-0.048.002.00135
GBMDPYD →+0.783+0.117<.001<.00135
LUADTIAM1_S358 →+0.526+0.104<.001<.00135
GBMTRIM47_S588 →+0.368+0.117<.001<.00135
GBMIFI16 →+0.564+0.146<.001<.00135
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration