Response to platelet-derived growth factor

Across TCGA cell cohorts, RNA activity of the Response to platelet-derived growth factor pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UCHL5, ZNF254, and FANCC, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UCHL5 grouped by Response to platelet-derived growth factor-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	UCHL5 →	+0.608	+1.147	.008	.004	3	4
BREAST	ZNF254 →	+0.907	+0.753	.005	.003	3	3
LIVER	FANCC →	+1.443	+1.517	<.001	.002	3	3
CNS	HS1BP3 →	-0.622	-0.524	.004	.008	3	3
CNS	EML3 →	-0.574	-0.761	.001	.001	3	3
LUNG_SCLC	KLF12 →	+2.033	+0.958	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UCHL5 by Response to platelet-derived growth factor activity — LIVER

Explore this box plot interactively →