Fatty-acyl-CoA catabolic process

Across TCGA patient cohorts, RNA activity of the Fatty-acyl-CoA catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLHL13, ESPN, and HAGH, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty-acyl-CoA catabolic process activity versus KLHL13 in UCEC (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KLHL13 →	+0.829	+0.112	.002	.007	3	4
OV	ESPN →	+0.769	+0.132	.003	.001	3	3
CCRCC	HAGH →	+0.459	+0.107	<.001	.002	3	3
BRCA	AGTR1 →	-1.587	-0.192	.002	.004	3	3
LSCC	UBE2V1P15 →	-0.428	-0.131	.009	.001	3	3
LSCC	CEACAMP8 →	-0.312	-0.093	.006	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036115 vs KLHL13 — UCEC

Explore this scatter interactively →