Fatty-acyl-CoA catabolic process

Across TCGA cell cohorts, RNA activity of the Fatty-acyl-CoA catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP8B3, ARNTL, and NTAN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATP8B3 grouped by Fatty-acyl-CoA catabolic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ATP8B3 →	-0.166	-1.439	.001	<.001	3	4
BLOOD_Leukemia	ARNTL →	+0.155	+1.274	.008	.001	3	3
BLOOD_Leukemia	NTAN1 →	-0.173	-1.154	.006	.008	3	3
BLOOD_Myeloma	KRT85 →	-0.335	-0.124	.003	<.001	3	3
BLOOD_Myeloma	IQGAP1 →	-0.456	-0.145	.001	<.001	3	3
BLOOD_Myeloma	PEA15 →	-0.440	-0.144	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATP8B3 by Fatty-acyl-CoA catabolic process activity — LIVER

Explore this box plot interactively →