Fatty-acyl-CoA catabolic process

Across TCGA cell cohorts, RNA activity of the Fatty-acyl-CoA catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ELF4, AKAP3, and ATG4D, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fatty-acyl-CoA catabolic process activity versus ELF4 in PANCREAS (Pearson r = -0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ELF4 →	-1.181	-1.076	.003	.008	3	4
BLOOD_Leukemia	AKAP3 →	+0.485	+0.469	.002	.002	3	4
BLOOD_Leukemia	ATG4D →	+0.627	+0.473	<.001	.001	3	4
BLOOD_Leukemia	MUTYH →	+0.790	+0.673	.001	.002	3	4
BLOOD_Leukemia	IL18 →	-2.641	-0.542	<.001	<.001	3	4
LUNG_SCLC	RIMKLA →	+1.789	+0.224	.005	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036115 vs ELF4 — PANCREAS

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