Medium-chain fatty-acyl-CoA metabolic process

Across TCGA patient cohorts, RNA activity of the Medium-chain fatty-acyl-CoA metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NUDT8, HMCN1, and SCLY, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Medium-chain fatty-acyl-CoA metabolic process activity versus NUDT8 in HNSC (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NUDT8 →	+0.519	+0.132	<.001	<.001	3	6
UCEC	HMCN1 →	-0.419	-0.078	.004	<.001	3	6
LUAD	SCLY →	-0.458	-0.077	<.001	<.001	3	6
OV	WDR19 →	-0.428	-0.050	<.001	<.001	3	6
LSCC	SLIRP →	+0.418	+0.111	<.001	<.001	3	6
BRCA	DDX21 →	+0.734	+0.081	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036112 vs NUDT8 — HNSC

Explore this scatter interactively →