Medium-chain fatty-acyl-CoA metabolic process

Across TCGA patient cohorts, RNA activity of the Medium-chain fatty-acyl-CoA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COX6B1, TPH1, and SLC31A1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Medium-chain fatty-acyl-CoA metabolic process activity versus COX6B1 in OV (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	COX6B1 →	+0.500	+0.205	.006	.005	3	3
BRCA	TPH1 →	-0.520	-0.100	.006	.004	3	3
BRCA	SLC31A1 →	+0.506	+0.151	.003	.005	3	3
CCRCC	CES3 →	+1.243	+0.137	.005	.001	3	3
CCRCC	NIM1K →	-0.614	-0.115	<.001	.008	3	3
CCRCC	RNA5SP378 →	-0.297	-0.115	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036112 vs COX6B1 — OV

Explore this scatter interactively →