Alpha-linolenic acid metabolic process

Across TCGA patient cohorts, RNA activity of the Alpha-linolenic acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GINS1, GANAB, and MYBL2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Alpha-linolenic acid metabolic process activity versus GINS1 in LSCC (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GINS1 →	+0.533	+0.100	<.001	.005	3	6
HNSC	GANAB →	+0.358	+0.167	.001	<.001	3	6
HNSC	MYBL2 →	+1.161	+0.205	<.001	<.001	3	5
LSCC	TIMELESS →	+0.659	+0.202	.002	<.001	3	5
HNSC	HROB →	+0.769	+0.172	<.001	<.001	3	5
HNSC	CCNB2 →	+0.949	+0.175	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036109 vs GINS1 — LSCC

Explore this scatter interactively →