Alpha-linolenic acid metabolic process

Across TCGA cell cohorts, RNA activity of the Alpha-linolenic acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FKBP1A, HECTD3, and KLC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FKBP1A grouped by Alpha-linolenic acid metabolic process-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	FKBP1A →	-0.791	-1.393	<.001	<.001	3	5
LUNG_NSCLC_LUAD	HECTD3 →	-0.721	-0.875	.005	.005	3	4
BREAST	KLC1 →	-0.627	-0.825	.002	.004	3	3
LUNG_NSCLC_LUAD	AHDC1 →	-0.835	-0.796	.005	.003	3	3
LUNG_NSCLC_LUAD	IDH3G →	-0.827	-1.141	<.001	<.001	3	3
LUNG_NSCLC_LUAD	MAST2 →	-0.713	-0.768	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FKBP1A by Alpha-linolenic acid metabolic process activity — SOFT_TISSUE

Explore this box plot interactively →