Alpha-linolenic acid metabolic process

Across TCGA cell cohorts, RNA activity of the Alpha-linolenic acid metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACAA1, GALNT6, and MAP7, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Alpha-linolenic acid metabolic process activity versus ACAA1 in URINARY_TRACT (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ACAA1 →	+1.420	+0.501	.004	.002	2	7
LARGE_INTESTINE	GALNT6 →	+1.906	+0.301	.003	.001	3	6
SKIN	MAP7 →	+1.071	+0.191	.001	.001	3	5
LUNG_NSCLC_LUAD	TMEM105 →	+0.843	+0.268	.001	.003	3	5
URINARY_TRACT	POF1B →	+3.362	+0.426	<.001	.001	3	5
URINARY_TRACT	ANXA9 →	+2.017	+0.316	.006	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036109 vs ACAA1 — URINARY_TRACT

Explore this scatter interactively →