Leukotriene B4 metabolic process

Across TCGA patient cohorts, RNA activity of the Leukotriene B4 metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DTD2, ADGRG4, and FAM86GP, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Leukotriene B4 metabolic process activity versus DTD2 in COAD (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	DTD2 →	+0.671	+0.988	.005	.006	3	3
LUAD	ADGRG4 →	+0.066	+0.079	<.001	.001	3	2
PDAC	FAM86GP →	+0.452	+0.571	.002	.004	3	2
CCRCC	TMIGD3 →	+0.708	+0.184	.005	.003	3	2
CCRCC	PALLD →	+0.532	+0.170	.002	<.001	3	2
CCRCC	MATN2 →	+0.625	+0.163	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0036102 vs DTD2 — COAD

Explore this scatter interactively →