Leukotriene B4 metabolic process

Across TCGA cell cohorts, RNA activity of the Leukotriene B4 metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCT7, TLR1, and UFSP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CCT7 grouped by Leukotriene B4 metabolic process-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CCT7 →	+0.491	+0.989	.002	<.001	3	5
BREAST	TLR1 →	+1.257	+0.781	.006	.003	3	4
LARGE_INTESTINE	UFSP2 →	+0.592	+1.230	.002	<.001	3	4
LUNG_SCLC	ARRDC4 →	-1.606	-1.079	.001	<.001	3	4
STOMACH	ARHGDIB →	+3.651	+1.518	.002	<.001	3	4
LUNG_SCLC	CCT5 →	+1.293	+1.321	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCT7 by Leukotriene B4 metabolic process activity — OVARY

Explore this box plot interactively →