Leukotriene B4 metabolic process

Across TCGA cell cohorts, RNA activity of the Leukotriene B4 metabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERG, LSM1, and POT1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ERG grouped by Leukotriene B4 metabolic process-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ERG →	-0.155	-0.353	<.001	.004	3	5
BREAST	LSM1 →	-0.138	-0.656	.007	.009	2	5
BLOOD_Lymphoma	POT1 →	-0.496	-0.132	.001	.001	3	4
BLOOD_Leukemia	TBX15 →	+0.178	+1.684	<.001	<.001	3	3
BREAST	GHRL →	-0.183	-0.790	<.001	.006	3	3
LUNG_SCLC	PLCH1 →	+0.117	+1.451	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ERG by Leukotriene B4 metabolic process activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →